Since it is not 1997 anymore, doing the tangent space on-the-fly has some potential benefits, such as reduced complexity of asset tools, per-vertex bandwidth and storage, attribute interpolators, transform work for skinned meshes and last but not least, the possibility to apply normal maps to any procedurally generated texture coordinates or non-linear deformations.
For those unfamiliar with the topic, the motivation was to construct the tangent frame on the fly in the pixel shader, which ironically is the exact opposite of the motivation from : In the time since then I have refined this technique with lessons learned in real life. This post is a follow-up to my 2006 ShaderX 5 article about normal mapping without a pre-computed tangent basis.